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Other controlled weight loss drugs (older amphetamines, Schedule II stimulants) face stricter scrutiny

Dose escalation can be delayed by 4 weeks if adverse effects persist, and treatment is not recommended for patients with severe gastrointestinal disease

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This review aims to provide the pathophysiology of AKI covering the intricate mechanisms underpinning AKI in the dynamic context of the clinical setting, the tailored role of inflammation and ischemia, and the cellular and molecular crosstalk pathways involved