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The other bar graphs on the right show the reduction in the number of events either in all 5 mg and 10 mg subjects (top bar chart) or the reduction of the number of events excluding subjects that did not have Level 2 or Level 3 events on placebo (bottom bar chart)
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This ramping up is sometimes referred to as titration, and is a common system for use with medications that cause certain side effects
No one likes talking about limiting access to effective drugs, but I believe its a strategic one. The explosion in popularity of expensive GLP-1 drugs, like Zepbound and Mounjaro, has been a driver behind the dramatic growth in state spending on health care
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