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These findings indicate that the mode of action of bempedoic acid on the lowering of hepatic lipids, and thus circulating LDL cholesterol levels, occurs through multiple distinct processes
Cellular uptake of LA has been shown to occur via several systems including the medium chain fatty acid transporter, a Na + -dependent vitamin transport system, and a H + -linked monocarboxylate transporter for intestinal uptake
In a cervical cancer cell line (HeLa), the compound reduced cell proliferation in a concentration- and time-dependent way and lowered expression of phospho-Akt and SIRT1, two proteins tied to tumor progression, while a non-cancer reference cell line was less affected
March 22, 2023
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