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At 20 M, 10-gingerol, 6-shogaol, 8-shogaol, and 10-shogaol reduced the secretion of IL-1 on LPS-primed and ATP-activated IL-1 secretion in THP-1 macrophages with the inhibitory values of 102.2, 95.2, 63.6, and 46.5%, respectively ( 6-Gingerol significantly increased the IL-10 level and decreased the Il-17 level in both bowel tissues and serum in dextran sulfate sodium (DSS)-stimulated ulcerative colitis mice model
Additionally, it suppresses the growth of orbital fibroblasts and reduces HSP72 expression induced by superoxide (111)
Tyrosinase is an enzyme that is involved in the production of melanin, and glutathione has been shown to inhibit the activity of tyrosinase, which can help to reduce the production of melanin
These compounds intervene in ferroptosis through multiple mechanisms, opening new therapeutic avenues for SCI
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