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About one in seven adults who have ever used GLP-1 medications say they are no longer using these drugs because of the cost (14%), similar to the share who report no longer taking the medications because of side effects (13%)
The secretagogue advantage is preserving the natural pulsatile pattern and avoiding exogenous GH's suppressive feedback, but this theoretical advantage has not translated into a demonstrated clinical superiority in head-to-head trials
Diabetes Care 33 , 17591765 (2010)
The current methods of subcutaneous injection or continuous infusion are not conducive to long-term management, and the development of a drug administration system with high patient compliance (such as oral or weekly injection) is still a major challenge
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