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Elizabeth Rebello, an anesthesiologist at the University of Texas MD Anderson Cancer Center, was one of the committee members who voted against allowing the four peptides to be compounded, citing unknowns around safety and confusion for the public
TB-500 binds monomeric G-actin through the central LKKTETQ motif, sequestering actin monomers and modulating the cytoplasmic pool available for filament elongation in cell-based assays
Further research is warranted to elucidate its optimal usage in clinical practice
WARNINGS: Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy
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