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In addition to the primary injury and its complications, the secondary phase of the injury also causes numerous health issues
Neutrophils recruited to the liver release proteases, ROS, and NETs, which are the primary mechanisms underlying liver injury [84, 173]
Moreover, TMZ also has other benefits to the myocardium, including increased coronary blood flow reserve, maintenance of cardiac energy metabolism, anti-apoptosis, and anti-inflammation
Blood pressure changes can also be a potential side effect
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