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Research shows that many of the benefits are obtained after daily use for 2-3 years

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DSIP crosses the blood-brain barrier freely an unusual property for a peptide of its size via a non-competitive, non-saturable passive mechanism whose physicochemical determinants (lipophilicity, charge, molecular weight, and protein-binding) are now well characterised

In research models the GHRH analogue increases the release that comes free per stimulus, while the ghrelin receptor agonist adds a second, independent stimulus