As a typical mitochondrial - targeted peptide, SS-31 (elamipretide) can stabilize cardiolipin in the inner mitochondrial membrane, reduce electron leakage to inhibit ROS, inhibit the opening of mPTP to reduce the release of mtDNA and cell apoptosis, protect mitochondria and exert anti - inflammatory effects, and is effective on immune cells and parenchymal cells such as cardiomyocytes
/ Address: 44-20, Tongil-ro 1888beon-gil, Munsan-eup, Paju-si, Gyeonggi-do, Republic of Korea
Liu Y, Ma W, Zhang P, He S, Huang D
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop