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Unlike its single-pathway predecessors, tirzepatide dual-action mechanisms tackle weight loss by reducing appetite, slowing digestion, and increasing insulin sensitivity
In animal models, it has been linked to reduced fat gain, better insulin sensitivity, and lower metabolic inflammation, largely by strengthening the gut barrier and limiting the leakage of inflammatory compounds
Gut Microbes , 11(4), 855866
Rats were acclimated to the experimental conditions by daily handling during 7 days
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