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The peptides mechanism involves facilitating copper uptake into cells, as characterized by Pickart et al

A 12-week study in humans where participants were given 500mg of berberine 3 times a day resulted in: an average weight loss of 5lb (2.3kg) a 23% reduction in triglycerides (a type of blood fat) a 12.2% reduction in cholesterol However, animal studies show that berberine has a very low bioavailability of less than 1% (how much of it is absorbed in your bloodstream), which may affect its effectiveness