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Animal studies have also reported reductions in adipocyte size, improvements in whole-body energy expenditure, and altered lipid metabolism following pharmacological NNMT inhibition

This section is not dosage guidance and must not be interpreted as instructions for administration

It failed to gain approval for obesity treatment following Phase II clinical trials in the mid-2000s, and no regulatory body has since approved it for any human indication

However, the body weight of 5A-1MQ-treated obese mice (WD/LD-T group), which was indistinguishable from the other DIO groups at study start, was indistinguishable from the lean control (LD/LD-V) group at study completion (results with FDR correction