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In the classical model, L cellderived GLP-1 is secreted in response to feeding and acts as an endocrine hormone to signal through the cell GLP-1R to potentiate GSIS (10)
Reduces fat: GH participates in the lipolysis process and helps to break down body fat [4]
In the intestinal L-cells, proglucagon is cleaved by the enzyme prohormone convertase 1/3 to produce GLP-1, along with other peptides including GLP-2 and glicentin
This results in modest reductions in hemoglobin A1c (HbA1c), body weight, and systolic blood pressure, largely mediated through osmotic diuresis and natriuresis [19]
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