when to increase glp-1 dose Titration: How Fast Should You Increase? when to increase glp-1 dose

In Phase 3 studies: Participants without diabetes taking orforglipron lost approximately 9% to 10% of body weight over roughly 36 to 40 weeks Participants with type 2 diabetes generally lost around 7% to 8% By comparison, Wegovy's landmark STEP trials reported approximately 14.9% average weight loss over 68 weeks

GLP-1, or glucagon-like peptide-1, is a naturally occurring hormone in the human body that plays a critical role in regulating blood sugar levels, appetite, and insulin secretion

Data are expressed as arbitrary units over control, which was assigned a value of 1

Later work showed it does far more, influencing the activity of roughly 4,000 genes tied to repair and aging