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I think the direction of travel is the same, but there could be both an upside and a downside to our guidance depending on the pace of approval of generics in Canada. BMO does not expect the issue to spill over to the U.S
For instance, tirzepatide has led to a 23% reduction in body mass among perimenopausal females
That pattern is common on GLP-1 medications because delayed gastric emptying and appetite suppression can make normal portion sizes feel heavy
For example, in both neurodegenerative diseases like Alzheimer's and Parkinson's, the presence of fewer bacteria generating SCFA and the increased density of proinflammatory microbes lead to neuroinflammation and cognitive decline
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