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Factors that influence this include: Baseline B12 levels Symptoms and severity Absorption issues or medical conditions Diet and lifestyle factors Some people maintain healthy levels with occasional injections, while others require more consistent support

How does vitamin B12 deficiency cause neuropathy

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Its most cited proposed mechanism is an increase in brain-derived neurotrophic factor (BDNF) and its receptor TrkB, alongside modulation of monoaminergic systems (dopamine, serotonin) and the melanocortin pathway [3] [4]