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These include (i) rational drug combinations targeting parallel or converging signaling cascades, (ii) the use of allosteric inhibitors or degraders that disrupt key signaling hubs, (iii) vertical inhibition along a single pathway to prevent upstream feedback reactivation, and (iv) the application of systems biology and network modeling to predict synthetic lethal vulnerabilities
UCP1 is expressed in brown adipose tissue (BAT), UCP2 is expressed in a number of tissues, and UCP3 is expressed in skeletal and heart muscle
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