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DOI 10.1158/1535-7163.MCT-09-0560
Key Clinical Interpretation Clinical Interpretation In clinical practice, the most consistent determinant of nutritional adequacy during GLP-1 therapy is not the medication itself, but the structure of the patients reduced intake
The timeframe is urgent, she says, as barriers to using these drugs already are falling, including cost, more readily accessible formats like pills over injections, and scientifically proven efficacy for a variety of health issues
In a phase II dose-finding study, oral semaglutide doses of 2.5 mg to 40 mg co-formulated with 300 mg SNAC improved glycemic control, with a dose-dependent mean reduction in HbA 1c of up to 1.9% versus 0.3% for placebo, from a mean HbA 1c level of 7.9% (standard deviation: 0.7%) [59]
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