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doi: 10.3390/diagnostics11020219
Free copper promotes free radical damage and collagen breakdown leading to accelerated skin aging
The mechanism involves IGF-1-mediated stimulation of osteoblast proliferation and enhanced collagen synthesis in bone matrix
Central satiation via the area postrema The principal site of amylin action studied in experimental models is the area postrema, a circumventricular organ in the brainstem that lies outside the bloodbrain barrier and is therefore directly accessible to circulating peptides
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