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(A) Senolytic agents selectively induce the apoptosis of senescent cells by inhibiting the pro-survival signaling pathways, including PI3K/Akt, BCL-2 family proteins, p53/MDM2, and HSP90

For example, previous studies have shown that cancer-related fatigue that lasts up to a year may be due to unresolved inflammation (Feng et al., 2017, 2018a), whereas acute fatigue during radiation therapy with neoadjuvant ADT may be related to anemia and mitochondrial dysfunction (Feng et al., 2015, 2018b)

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