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Most striking, IAPP toxic oligomers appear to disrupt membranes of the secretory pathway, and then when adjacent to mitochondria, disrupt mitochondrial membranes ( Figure 4 illustrates schematically the process by which Akkermansia spp protect the host from type II diabetes

Among these, there were electrophiles with warheads that target either cysteines (for example, acrylamides or chloroacetamides) or other nucleophilic residues such as lysine (for example, aldehydes or sulfonyl fluorides)