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8.6 Renal Impairment Compared to healthy volunteers with normal renal function, patients with moderate and severe renal impairment as estimated by the Cockcroft-Gault equation had higher exposures to phentermine and topiramate
These agents lack hepatic metabolism and hence have limited drugdrug interactions, but they do slow gastric emptying, potentially impairing immunosuppressant absorption
Recognizing these warning signs early can help prevent complications
Yki-Jrvinen, H., Fatty liver: a novel component of the metabolic syndrome
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