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The study noted functional behavioral benefit starting on day 7 and up to the full 60 days duration of the study.9 Another randomized blinded placebo-controlled trial in mice administered methylene blue 1mg/kg one hour post TBI and 0.5mg/kg three hours post TBI and evaluated the mice via behavioral assessments and MRI over the following 14 days

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The study established that FOXO4 maintains senescent cell viability by targeting p53 to the nucleus and preventing apoptosis, and that disrupting the FOXO4-p53 interaction with FOXO4-DRI causes p53 nuclear exclusion and cell-intrinsic apoptosis in ionising radiation-induced and doxorubicin-induced senescent IMR90 fibroblasts

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