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As known, ROS are free radicals and/or oxygen derivatives that include superoxide anion, hydrogen peroxide, hydroxyl radical, lipid hydroperoxides, peroxyl radicals, and peroxynitrite
A laboratory-deficient vitamin B12 deficiency can occur in: Years of lack and malnutrition (eg due to strict vegetarian diet)
For example, if phenytoin levels are therapeutic, the administration of a drug competing for protein binding could double the free phenytoin level (if protein binding decreases from 90% to 80%)
These observations underscore the importance of precision medicine approaches, particularly when repurposing DM2 therapies like metformin for AD prevention
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