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6.4.2 Deleterious interactions with other growth factors Further supporting the complexity of crosstalk between IGF-1R and other tyrosine kinase receptor pathways, unclear synergistic actions of EGF, PDGF, TGF-, and IGF induce stemness, cancer progression and metastasis, drug resistance, and tumor relapse in various cancer types (33, 39, 53, 77)

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