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You may need B12 injections if you: Have been diagnosed with pernicious anemia Have gastrointestinal issues (e.g., Crohns disease, celiac disease, or after bariatric surgery) Follow a strict vegan or vegetarian diet without adequate supplementation Are over the age of 50, as absorption decreases with age Take certain medications that interfere with B12 absorption Have chronic fatigue, memory issues, or nerve problems due to B12 deficiency

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Given the robustness of this mitochondrial response, the multifaceted nature of PGC1 regulation in cells and a modest rescue at best by mTORC1 inhibition, we suspect that there is a degree of functional redundancy built into this metabolic plasticity system that can contribute to such an adaptive response, and complete inhibition of this system will prove difficult

Drug interactions: No formal drug interaction studies exist