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267 GAS6, secreted by stromal cells such as CAFs and macrophages, binds to AXL, promoting its dimerization, autophosphorylation, and activation of downstream survival pathways, including the PI3K/AKT, MAPK/ERK, and NF-B pathways

Severe nausea requiring treatment discontinuation was rare in monotherapy trials, with only about 1% of participants in the REDEFINE 1 trial stopping treatment because of adverse events overall

Research Overview GLP-2 receptor agonists, including cagrilintide, have been extensively studied for their role in promoting intestinal growth, enhancing nutrient absorption, and modulating gut motility

Companion Supplies & Routine Support CagriSema Reconstitution Guide Reconstitution math depends on vial size and the dose you intend to draw each week