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Alpha-MSH interacts with various melanocortin receptors (MCRs) in the body, affecting multiple physiological processes

Fractionation of this sleep-promoting blood eventually yielded a small nine-amino acid peptide that could reproduce these effects, and Monnier and colleagues published their findings in 1977, entering the compound into the scientific literature as Delta Sleep-Inducing Peptide

The two have never been compared directly

But if oral amycretin can deliver 1520% weight loss over a full treatment course (which the early trajectory suggests is plausible), that would make it the most effective oral obesity medication ever developed