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95% CI 0.14, 2.05
Rigorous, adequately powered randomised controlled trials, with standardised background therapy, longitudinal biomarker sampling, and patient-reported outcomes, are now needed to determine efficacy, optimal candidates, and durability of response
Pharmacological activation of Nrf2 enhances the expression of cytoprotective genes, conferring resistance against oxidative injury and fibrogenesis in DKD models (242)
No significant differences between control and PXN LOW were observed in aged animals, although a trend was present ( P = 0.07)
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