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SURPASS trials demonstrate HbA1C reductions of 2.0-2.5% on average, superior to most oral antidiabetic agents and comparable to or better than insulin
(Outlines contraindications for niacin therapy, including active peptic ulcer disease, active liver disease with elevated enzymes, hypersensitivity to niacin, and arterial bleeding, as well as monitoring recommendations for blood pressure, glucose, uric acid, etc., due to niacins systemic effects)
As a result, no significant change in the total contributions of U 13 C-glucose to glutamate, serine or glycine was observed (Fig
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