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Its defining modification is a trans -3-hexenoyl group attached to the N-terminal tyrosine, a chemical change designed to protect the peptide from rapid cleavage by dipeptidyl peptidase-4 (DPP-4), the enzyme that quickly inactivates native GHRH
By engaging two pathways simultaneously, tirzepatide may enhance appetite suppression, improve insulin sensitivity, and boost metabolic rate more powerfully than single-action agents
Kevin says
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