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To isolate the effect of GLP1 medication, the researchers compared people using GLP-1 medication with similar people who only used metformin (another diabetes medicine)
The initial step in designing a PCSK9/GLP-1 dual molecule was to fuse a DPP-4-resistant GLP-1 analogue peptide with either GGSA or [G 4 S] 3 A linkers to the heavy or light chain variable domains of a panel of anti-PCSK9 antibodies
Then taper the supplement and monitor whether the effects persist through dietary maintenance alone
For a healthy man, this is manageable
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