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To investigate the metabolite profile of Down syndrome using the model, we began by increasing by 50% the V max of CBS, since the gene for CBS is on chromosome 21 and is expressed at 150% of normal
What the evidence is preclinical actually means for a reader Preclinical means the findings come from cell cultures and animal models, not from controlled human trials
It is involved in the synthesis of essential molecules like glutathione, heme, and creatine
Middleton, 2023)
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