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Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid: A 3-week multicentre randomized controlled trial (ALADIN Study)

A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, thereby being roughly four times higher than those in normal rats

FIGURE 2 In addition to high mitochondrial ROS emission, vitiligo patients have a deficient EAS, with low activity and low gene expression of catalase (CAT), glutathione peroxidase (GPx), and thioredoxin reductase (TrxR) (Xie et al., 2016), leading to a chronic OS state (Schallreuter, 2014)

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