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SGLT2 inhibitors stimulate hepatic glucose production and also increase glucagon secretion, which promotes endogenous glucose production and restricts their glucose-lowering capacity [34]
As tirzepatide promotes substantial weight reductionclinical trials such as SURMOUNT-1 demonstrated average weight loss of approximately 20.9% of body weight at the 15 mg dose in adults without diabetesthis metabolic shift can influence the hypothalamic-pituitary-ovarian axis that regulates menstruation
Consensus report: definition and interpretation of remission in type 2 diabetes
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