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Activation of FXR by the gut microbiota was shown to reduce the expression levels of most bile acid synthesis enzymes and inhibit the expression of gluconeogenic genes (201, 202), thereby linking the intestinal microbiota to the regulation of bile acids and metabolic homeostasis
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Tirzepatide improves glycemic control by lowering fasting and postprandial glucose levels in people with T2D through several mechanisms, including improved beta-cell function and insulin sensitivity, reduced glucagon levels and delayed gastric emptying (although this delay diminishes over time) [Citation36,Citation37]
