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H4 receptors are found in the bone marrow, basophils (a type of white blood cell), the thymus, small intestine, spleen, colon, and mast cells.[ref] Histamine receptors in the gut: The H1, H2, and H4 receptors all play a role in the way your intestines function, and this gives rise to the digestive problems seen in people with histamine intolerance

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Presented for research literature review only Miwa T et al