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Carnitine and its derivatives exist in a dynamic carnitine pool within the body
If personnel take pyridostigmine in advance of exposure, soman will be prevented from binding to a significant percentage of available synaptic AChE because the AChE binding sites will be transiently occupied by pyridostigmine, and so irreversible soman aging (formation of a covalent bond) to the enzyme cannot take place
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Farxiga is now approved by the USA and the EU for adult symptomatic heart failure as standalone indications
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