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Patients with a prior history of serious gastrointestinal adverse events and other known risk factors that are associated with peptic ulcer disease ( alcoholism, smoking) are at increased risk
SURPASS-CVOT (N=13,165) noninferior on 3-point MACE (HR 0.92), with 4-point MACE HR 0.88 and all-cause death HR 0.84: Heerspink SURPASS-4 kidney post-hoc
Placebo effects are impossible to separate from genuine responses
Signs of Contamination to Watch For Cloudy solutions indicate possible bacterial contamination risks
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