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Impaired FAD-dependent enzyme activity is also detrimental to bloodbrain barrier (BBB) integrity, leading to downregulation of tight-junction proteins such as claudin-5 and occluding, increased permeability, and enhanced peripheral immune infiltration
It's often recommended to keep them refrigerated to maintain their integrity and prevent them from melting before use
This microbial-dependent activation of the cGASSTING-IFN-I axis occurs indirectly, without requiring direct host-microbe interactions
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