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Their functional plasticity, shifting between inflammatory, repair, or anti-inflammatory states, depends on metabolic adaptation and lipid remodeling, including choline uptake and phospholipid reorganization ( 2.1.1 Macrophages and dendritic cells Macrophage functions, such as cytokine and chemokine secretion, phagocytosis, and organelle biogenesis, are intricately linked to membrane phospholipid composition, curvature, and charge ( Figure 3 )

4:389-398 (2013) Hajar-Azhari S, Wan-Mohtar W, Ab Kadir S, Rahim MHA, Saari N