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Senescent Chondrocyte Removal & Chondrogenic Potential Restoration (PMC, 2021) FOXO4-DRI Removes Replication-Stress Senescent Chondrocytes in ACI Research Model A study published in PMC investigated FOXO4-DRI in the context of autologous chondrocyte implantation (ACI) a procedure in which in vitro chondrocyte expansion generates a senescent cell burden that adversely affects cartilage formation quality and quantity
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2016;55:153157 [4] Kern JK, Geier DA, Adams JB, Garver CR, Audhya T, Geier MR
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