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Senolytics clear existing senescent cells
Nitric Oxide (NO) is one molecular mediator involved in both the inflammatory response [34] and oxidative damage [6, 35]
Front Pharmacol 11:265 Holmstrm KM, Finkel T (2014) Cellular mechanisms and physiological consequences of redox-dependent signalling
If the cells supply of glutathione is severely depleted and GSSG trafficking out of the cell exceeds the rate at which it can be reduced back to GSH, cellular defence against oxidative stress is impaired and the cell may experience critical membrane failure and even cell death as a result of lipid peroxidation due to lack of protective glutathione antioxidant action
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