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Anecdotally, however, we know that plenty of people (lots of Wirecutter staffers among them!) swear by this step in their skin-care and self-care routines

The long-term significance of anti-drug antibody formation (observed in over half of treated subjects) and its interaction with native incretin hormones requires continued study

Patients with uncontrolled tachyarrhythmias, recent acute coronary syndrome, or unstable heart conditions should exercise caution and require thorough cardiovascular assessment before starting treatment

For people without a gallbladder, this is especially important because managing weight can be a long-term challenge