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PMID: 30483779 Sci Rep Pomolic acid alleviates CCl4induced liver fibrosis in mice by suppressing -arrestin 2-mediated pro-fibrotic macrophage polarization
By identifying biological mechanisms rather than isolated genes, the analysis helps explain why some patients experience strong, durable benefit while others do not, supports quantitative prediction of response magnitude and tolerability, and provides a mechanistic foundation for more precise prescribing and drug-specific stratification as the GLP-1 class continues to expand
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