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Madrigals 2025 licensing agreement with CSPC Pharma for an oral GLP-1 receptor agonist (MGL-2086) is a direct strategic response to the combination therapy opportunity: Rezdiffras THR-beta mechanism and a GLP-1 mechanism are pharmacologically additive in addressing the steatotic and fibrotic components of MASH, and a fixed-dose combination would reset the Orange Book listing and potentially provide a new exclusivity runway into the early 2050s
Technically, for people with type 2 diabetes, but it's regulating my blood sugar and just like, killing the fat."
These side effects may feel stronger compared to liraglutide
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