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In mice studied under regular chow diet conditions, both pharmacological inhibition of local gut DPP-4 and systemic inhibition of DPP-4 activity as well as genetic inactivation of Dpp4 leads to an increase in plasma active GLP-1 and a reduction in postprandial TG excursion
Although the histaminergic system is not the only transmitter system implicated in atypical antipsychotic-induced weight gain, strong evidence suggests its ability to influence food intake, and sensitivity to these medications, plays a contributing role
As of early 2026, only 16 states cover GLP-1s for obesity
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