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Although cyanocobalamin is more readily absorbed, much of it is excreted through the urine before it can reach the cells Cyanocobalamin vs Hydroxocobalamin In comparison to hydroxocobalamin, cyanocobalamin has a significantly worse absorption rate and storability, which is why today mostly hydroxocobalamin is used in B12 injections

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A national cohort study published in Lancet Psychiatry this month followed close to 100,000 Swedish patients with depression or anxiety who also carried a diagnosis of type 2 diabetes or obesity