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Uptake of extracellular asparagine prevents the death of glioblastoma cells in response to glutamine depletion by blocking the apoptotic function of a glutamine-induced endoplasmic reticulum stress marker protein, ATF4, and by increasing glutamate-ammonia ligase (GLUL)-mediated glutamine and protein synthesis 116,117
The CDSs of Gh_A12G2084 and Gh_D12G2260 were also cloned by PCR and we found that there was a deletion of 13-bp nucleotide sequence behind the 675-bp nucleotide (from the start codon, marked with yellow in Supplementary Data 1) of Gh_A12G2084 and Gh_D12G2260 , this frame shift error evoked the emergence of a termination codon (marked with red in Supplementary Data 1)
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