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We find that KMT2A-r leukemia is highly sensitive to MR and show a profound impact of MR on the metabolome and epigenome

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A reader who understands the actual structural problem can ask better questions of any unpatentable therapeutic, and tell promising-but-untrialled apart from suppressed-but-proven

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Acknowledgements This project was supported by Fundao de Amparo Pesquisa e Inovao do Estado de Santa Catarina (FAPESC), Universidade do Extremo Sul Catarinense (UNESC), Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico of Brazil (CNPQ), and Fundao Coordenao de Aperfeioamento de Pessoal de Nvel Superior of Brazil (CAPES)

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